Prophylactic efficacy of drugs against equine piroplasmidosis in Gorny Altai

The purpose of the research is to study prophylactic efficacy piroplasmicides and elucidate effect doses Imidocarb Dipropionate on pathogen viability. Materials methods . Babezan 12% was intramuscularly injected 150 horses based active substance at 2.5 mg/kg body weight Neosidin M 30 twice a dose mL per 100 kg live with 15-day interval. control group animals did not receive drug. clinical follow-up experimental animals’ condition done for 72 days. Before experiment 14 days after drugs, blood samples were examined by nested PCR in presence genus-specific primers from 18S rRNA gene sequence Babesia spp. / Theileria DNA. Species identification genotyping detected Piroplasma performed sequencing fragments. Results discussion Among 12 horses, 8 (66.7%) had Piroplasmida DNA found samples, which 50.0% identified as equi 16.7% caballi A high T. prevalence (over 50.0%) indicates an endemic course equine theileriosis. Babesan early chemotherapy helped prevent incidence theileriosis within 48 59 Double interval prevented morbidity 52 preventive no viability persistent stages.